3 credits
Fall 2025 Lecture
The goal of this is to provide students a comprehensive knowledge of concepts related to drug absorption, distribution, metabolism, excretion and action and the relationship to pharmacokinetics parameters such as bioavailability, clearance, volume of distribution, and half-life; and physiological and pharmacological factors affecting these parameters. At the end of the course, students are expected to communicate effectively, establish a basic understanding at a clinical utility skill level of fundamental PK and PD terminology and principles. Provide a working-knowledge level understanding of the mathematics of PK and PD. Clearly distinguish and characterize the use of PK/PD as tools in Research (Discovery), Drug Development (Characterize PK/PD), and Clinical Therapeutics (TDM, Drug Interactions). Provide participants with the basic skills of PK/PD providing an understanding of the scope, complexity and critical importance these disciplines to their use in Research, Drug Development, and Clinical Therapeutics. Permission of instructor required.
Learning Outcomes1Develop the vocabulary of PK and PD and be able to understand and grasp the significance of using PK/PD tools in drug discovery, development, clinical use, and research.
2Understand and apply the fundamental mathematical relationships of PK/PD.
3Design, conduct, and analyze research studies in animals or human subjects that employ the research tools of pharmacokinetics and/or pharmacodynamics to describe the properties of drugs or compounds under research investigation using standard techniques.
4Understand the significance of key relationships in PK and PD and be able to apply that understanding to other drugs and circumstances.
Restrictions
made by Purdue students.