1 credit
Fall 2025 Lecture Upper Division
This course is designed to provide students with a working knowledge of fundamental concepts in pharmacokinetics and research methodology. In particular, students will learn the importance of determining and deploying the pharmacokinetics of experimental therapeutic agents to appropriately design and analyze preclinical studies in drug discovery.
Learning Outcomes1Define the concepts of clearance, volume of distribution, half-life, and systemic availability.
2Define the key concepts for quantifying drug response, including ED50, EC50, Emax, IC50, and TD
33. Describe the key elements of hypothesis formulation and testing.
4Define the terms specificity, selectivity, and sensitivity as they regard to experimental data.
5Use basic concepts of experimental methodology, design a basic study to determine the pharmacokinetics of a drug in a species after intravenous administration of an experimental drug.
6Provide EC50 data from cell studies on the effects of an experimental drug, design a study to determine the dose needed to achieve the EC50 in a given species.
7Formulate a hypothesis and design a study to determine the effects of an experimental agent on a model disease, including measures of reproducibility and appropriate data analysis.
8Design a basic study to assess the reproducibility of an assay.
Prerequisites
Restrictions
made by Purdue students.