1Describe the general physiological processes and factors that influence drug dissolution, absorption, distribution, metabolism and excretion.

2Define and describe the pharmacokinetic features of parallel, sequential, and reversible first-order processes. Define and describe the pharmacokinetic features of zero-order and first-order, and Michaelis-Menten processes.

3Anticipate the effects of altering rate and extent of absorption, clearance, volume of distribution on the amount of drug in the body following an oral dose.

4Define and describe the pharmacokinetic parameters and equations used to calculate the loading and maintenance dose of drugs eliminated by first-order kinetics.

5Collect relevant patient information and relevant drug information data in order to calculate the appropriate loading and maintenance dose of a drug.

6Design and modify dosing regimens given patient-derived information such as plasma concentration vs. time data and dosing regimen.

7Quantitatively draw the concentration vs. time curves when clearance, volume of distribution or bioavailability changes and explain how the curves have changed.

8Define and describe relative and absolute bioavailability the factors controlling bioavailability from various routes of administration. Determine if absorption or elimination rate-limits drug absorption kinetics.

9Describe the pharmacokinetic parameters that determine the time course of active metabolite disposition. Determine if formation or elimination rate-limits active metabolite kinetics.

10Describe drug disposition based upon physiological determinants in terms such as organ perfusion, unbound intrinsic clearance, free fraction in plasma and in tissue.

11Describe, with examples, how altered physiology (e.g., renal disease, liver disease, pregnancy, advanced age) affects the disposition of drugs. Define and describe the principles of hemodialysis and how this alters the disposition of drugs.

12Define steady-state concentration and describe the controlling factors following a constant rate intravenous infusion. Use pharmacokinetic parameters to predict drug concentrations during and after a constant rate infusion, with or without a bolus dose.

13Define and describe the pharmacokinetic parameters and equations used to calculate the loading and maintenance doses of drugs. Predict the rate and extent of drug accumulation for a given regimen of fixed dose and interval.

14Define and describe the basic models used to characterize the kinetics of effect (pharmacodynamics).