The purpose of Dosage Forms I is to provide a foundation in the basic concepts of pharmaceutics that are the foundation of drug delivery. The course begins by presenting the molecular basis for aqueous and lipid solubility of drugs, pharmacokinetic principles that are related to dosage forms, mechanisms by which excipients or manufacturing processes affect bioavailability, and chemical kinetics applied to the shelf-life of dosage forms. The pharmaceutics principles are then applied to successively more complex liquid dosage forms: solution, emulsion, and suspension. The excipients that are required to prepare the dosage forms: buffers, preservatives, emulsifiers, suspending agents, wetting agents, etc., and the method of preparing each dosage form in both a compounding and manufacturing setting are covered.
Learning Outcomes1Explain the basic scientific principles involved in drug delivery such as dissolution, chemical stability, physical stability, content uniformity, and bioavailability.
2Describe the essential scientific principles involved in the design of solutions, emulsions, suspensions, as well as dermatological and ophthalmic dosage forms.
3Evaluate the quality parameters of dosage forms that are involved in product selection.
4Analyze and interpret the results of bioequivalence studies that are important in product selection.
5Advise patients on the proper use and storage of liquid dosage forms.
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made by Purdue students.